A goal in each half from Diego Forlan helped Uruguay to a 3-0 victory over hosts South Africa who finished with 10 men after keeper Itumeleng Khune was sent off in their World Cup Group A match on Wednesday.
South Africa said they were caught cold by Uruguay's early goal in Wednesday's World Cup clash in Pretoria and found themselves unable to fight their way back into the game.
Wales Goalkeeper Wayne Hennessey received the first red card of the Qatar World Cup on Friday, when he was sent off for clattering into Iran's Mehdi Taremi outside the area late in the match.
Brazil failed to make a winning start despite home advantage, a multi-million dollar strike force and a man advantage as they were held 0-0 by South Africa in their opening soccer match at the Rio Olympics on Thursday.